Got a honeydew melon from the store, and I thought, why not plant the seeds from it? Is there any reason why this wouldn't work?

Most produce that you get from stores are hybrids and the seeds don’t reproduce true to type. Even so, it still might be fun to try and see what you do get.

I often eat melons outside and spit the seeds out, resulting in various sprouts. I've let some grow over the years, and NEVER has one of those volunteers grown any kind of yummy fruit. The results usually have been some sort of strange looking, unknown item, or perhaps the fruit looked good, but had no sweetness. If you have plenty of room in your garden, go ahead and let the seeds grow, see what results. But if room is tight, I'd buy seeds and plant those instead, as seed packets have seeds that will grow and provide fruit as described on the packet.

Keep in mind that the fruits you buy in stores is picked before they are ripe and the seeds have been able to mature, so what you have may not be viable seeds, in addition to what Major said.

Thanks for the advice, guys! I'll play it safe and buy seeds, since I don't have extra space in my gardens.

This was a good question. So I won't rely on those volunteers from a cantalope that I tossed into the lasagna beds. Must move them to make space for tomatoes!